The effect of some CNS depressants on the hypermotility and anorexia induced by amphetamine in rats

This study examines the effects of chlorpromazine, tetrabenazine, and chlordiazepoxide on the hypermotility and anorexia caused by amphetamine 11.5 mg/kg per os in rats. Each CNS depressant was used at three dose levels and was administered simultaneously with amphetamine. Chlorpromazine, 2 mg/kg, potentiated the hypermotility caused by amphetamine as measured in jiggle cages. Higher doses antagonized amphetamine stimulation. In rats which were trained to eat during a 5-h period, all doses of chlorpromazine potentiated amphetamine anorexia. Tetrabenazine antagonized amphetamine stimulation but did not affect its anorexic effect. Chlordiazepoxide antagonized both effects of amphetamine.