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1977•British Journal of PharmacologyOpen access

ACTIONS OF 16‐ARYLOXY ANALOGUES OF PROSTAGLANDIN F2α ON PREPARATIONS RESPONSIVE TO PROSTAGLANDIN ENDOPEROXIDES

Robin L. Jones, C.G. Marr

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Abstract

On four prostaglandin endoperoxide-sensitive preparations, namely human platelets in vitro, rabbit aortic strip, guinea-pig tracheal chain and pig blood pressure, ICI 79939 and its 11-oxo analogue mimicked the actions of 11,9-(epoxymethano) prostaglandin H2, and were considerably more active than either prostaglandin F2alpha or ICI 81008. It is suggested that this activity of ICI 79939 may contribute to its toxicity in experimental animals.

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On four prostaglandin endoperoxide-sensitive preparations, namely human platelets in vitro, rabbit aortic strip, guinea-pig tracheal chain and pig blood pressure, ICI 79939 and its 11-oxo analogue mimicked the actions of 11,9-(epoxymethano) prostaglandin H2, and were considerably more active than either prostaglandin F2alpha or ICI 81008. It is suggested that this activity of ICI 79939 may contribute to its toxicity in experimental animals.

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Available abstract

On four prostaglandin endoperoxide-sensitive preparations, namely human platelets in vitro, rabbit aortic strip, guinea-pig tracheal chain and pig blood pressure, ICI 79939 and its 11-oxo analogue mimicked the actions of 11,9-(epoxymethano) prostaglandin H2, and were considerably more active than either prostaglandin F2alpha or ICI 81008. It is suggested that this activity of ICI 79939 may contribute to its toxicity in experimental animals.

Key concepts: Prostaglandin, Prostaglandin F2alpha, Guinea pig, Chemistry, In vitro, Prostaglandin analogue, Prostaglandins F, Prostaglandin E

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ACTIONS OF 16‐ARYLOXY ANALOGUES OF PROSTAGLANDIN F2α ON PREPARATIONS RESPONSIVE TO PROSTAGLANDIN ENDOPEROXIDES — Research Paper | ScholarLens