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2006•Clinical Nuclear MedicineRequires access

Changing Nodule Activity With Time on Tc-99m Pertechnetate Thyroid Scintigraphy

Özhan Özdoğan, Yaşar Imren, Işıl Topcu, Duygu Gürel, Haluk Vayvada, Hatice Durak

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Abstract

A patient with a diagnosis of malignant melanoma was found to have a multinodular goiter on routine examination. Thyroid function tests revealed normal free T4 and TSH levels. A multinodular goiter was confirmed by thyroid ultrasonography with the dominant nodule located at the isthmus. Tc-99m pertechnetate thyroid scintigraphy did not reveal nodule activity. Delayed imaging was performed for localization of the dominant nodule with a marker. Surprisingly, the nodule was found to be hyperactive. The nodule was normoactive on I-131 thyroid scintigraphy. Fine needle aspiration biopsy confirmed a colloid nodule with follicular epithelial cells.

About this research paper

What this paper is about

A patient with a diagnosis of malignant melanoma was found to have a multinodular goiter on routine examination. Thyroid function tests revealed normal free T4 and TSH levels. A multinodular goiter was confirmed by thyroid ultrasonography with the dominant nodule located at the isthmus. Tc-99m pertechnetate thyroid scintigraphy did not reveal nodule activity. Delayed imaging was performed for localization of the dominant nodule with a marker. Surprisingly, the nodule was found to be hyperactive. The nodule was normoactive on I-131 thyroid scintigraphy. Fine needle aspiration biopsy confirmed a colloid nodule with follicular epithelial cells.

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Available abstract

A patient with a diagnosis of malignant melanoma was found to have a multinodular goiter on routine examination. Thyroid function tests revealed normal free T4 and TSH levels. A multinodular goiter was confirmed by thyroid ultrasonography with the dominant nodule located at the isthmus. Tc-99m pertechnetate thyroid scintigraphy did not reveal nodule activity. Delayed imaging was performed for localization of the dominant nodule with a marker. Surprisingly, the nodule was found to be hyperactive. The nodule was normoactive on I-131 thyroid scintigraphy. Fine needle aspiration biopsy confirmed a colloid nodule with follicular epithelial cells.

Key concepts: Medicine, Nodule (geology), Scintigraphy, Thyroid, Pertechnetate, Biopsy, Radiology, Pathology

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