1983•Journal of Labelled Compounds and RadiopharmaceuticalsRequires access

Synthesis of 35S‐ and 14C‐labeled famotidine, a new potent histamine H2 receptor antagonist

Kazuharu Tamazawa, Hideki Arima

Abstract

Abstract Famotidine, 3‐[[[2‐[(diaminomethylene)amino]‐4‐thiazolyl]methyl]thio]‐ N2‐sulfamoylpropionamidine, a new potent histamine H2 receptor antagonist, was labeled with 35S and 14C for metabolic studies at specific activities of 45.7 μCi/mg (VIb) and 47.6 μCi/mg (VIc) respectively.

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Available abstract

Key concepts: Famotidine, Chemistry, Histamine, Antagonist, Thio-, Histamine receptor, Histamine H2 receptor, Cimetidine