Synthesis of 1,2,4-Triazole-Functionalized Solid Support and Its Use in the Solid-Phase Synthesis of Trisubstituted 1,2,4-Triazoles
Alan R. Katritzky, Ming Qi, Daming Feng, Guifeng Zhang, Michael Griffith, Karen Watson
Abstract
Alan R. Katritzky, Ming Qi, Daming Feng, Guifeng Zhang, Michael Griffith, Karen Watson
Abstract
1,2,4-Triazoles were synthesized on a solid support in three steps, with excellent yields and purities. The utility of this triazole-functionalized solid support was demonstrated by the solid-phase synthesis of various trisubstituted 1,2,4-triazoles.
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1,2,4-Triazoles were synthesized on a solid support in three steps, with excellent yields and purities. The utility of this triazole-functionalized solid support was demonstrated by the solid-phase synthesis of various trisubstituted 1,2,4-triazoles.
Key concepts: Solid-phase synthesis, Chemistry, Combinatorial chemistry, Triazole, Phase (matter), Solid solution, Solid surface, 1,2,4-Triazole