Amar Saad, Michel Vaultier, A. Derdour
Abstract
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The 1,3-dipolar cycloaddition of nitrile oxides to 1-cyanoenamines gives 5-aminoisoxazoles regioselectively. Moderate to good yields could be obtained depending on the method used to generate the nitrile oxides. The intermediate isoxazolines could not be isolated.
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The 1,3-dipolar cycloaddition of nitrile oxides to 1-cyanoenamines gives 5-aminoisoxazoles regioselectively. Moderate to good yields could be obtained depending on the method used to generate the nitrile oxides. The intermediate isoxazolines could not be isolated.
Key concepts: Nitrile, Regioselectivity, Cycloaddition, 1,3-Dipolar cycloaddition, Chemistry, Organic chemistry, Combinatorial chemistry, Catalysis