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2001•Annals of Clinical Biochemistry International Journal of Laboratory MedicineOpen access

IgD Myeloma: A Potential Missed Diagnosis

David Sinclair, Tanya Cranfield

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Abstract

This report describes a case of IgD lambda myeloma which was discovered only following investigation of a suspicious 'low gamma region'. If anti-IgD investigations had not been carried out, it may have been misinterpreted as Bence Jones myeloma. The case illustrates that evaluation of serum and urine in cases of suspected myeloma is mandatory and that the possibility of IgD myeloma in cases that appear to be 'free light chain' paraproteins only should be investigated.

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What this paper is about

This report describes a case of IgD lambda myeloma which was discovered only following investigation of a suspicious 'low gamma region'. If anti-IgD investigations had not been carried out, it may have been misinterpreted as Bence Jones myeloma. The case illustrates that evaluation of serum and urine in cases of suspected myeloma is mandatory and that the possibility of IgD myeloma in cases that appear to be 'free light chain' paraproteins only should be investigated.

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Available abstract

This report describes a case of IgD lambda myeloma which was discovered only following investigation of a suspicious 'low gamma region'. If anti-IgD investigations had not been carried out, it may have been misinterpreted as Bence Jones myeloma. The case illustrates that evaluation of serum and urine in cases of suspected myeloma is mandatory and that the possibility of IgD myeloma in cases that appear to be 'free light chain' paraproteins only should be investigated.

Key concepts: Immunoglobulin D, Multiple myeloma, Medicine, Immunology, Antibody, B cell

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