2005•American Journal of DermatopathologyRequires access

Follicular Acantholysis: A Subtle Clue to the Early Diagnosis of Pemphigus Vulgaris

Meera Mahalingam

Abstract

The histologic hallmark of fully established pemphigus vulgaris (PV), a chronic autoimmune disease of the skin and mucosa, is the presence of acantholysis induced at the suprabasal level. This case report of acantholysis restricted to the follicular epithelium as a subtle histologic manifestation of the disease, draws attention to the pitfalls encountered in the histologic diagnosis of early cases of pemphigus vulgaris.

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Key concepts: Acantholysis, Pemphigus vulgaris, Pemphigus, Medicine, Pathology, Disease, Follicular phase, Autoimmune disease