ScholarLens Back to search
2012•Cell Biology Research & TherapyRequires access

Are Cancer Stem Cells Responsible for Cancer Recurrence?

Chelsea Grimes, David A. Margolin, Li Li

Open publisher page 6 citations

Abstract

Are Cancer Stem Cells Responsible for Cancer Recurrence? Local recurrence or distant organ metastasis are the major causes of cancer mortality. Conventional treatments, including surgery, chemotherapy, and irradiation, do not consistently prevent cancer recurrence. Thus, an alternative therapeutic approach is needed. Recent evidence indicates a specific cell population of cancer stem cells or tumor initiating cells (jointly CSC) exists in various cancers that may be identified by cell surface markers, such as CD133, CD44, aldehyde dehydrogenase 1 (ALDH1) enzyme expression, or side population.

About this research paper

What this paper is about

Are Cancer Stem Cells Responsible for Cancer Recurrence? Local recurrence or distant organ metastasis are the major causes of cancer mortality. Conventional treatments, including surgery, chemotherapy, and irradiation, do not consistently prevent cancer recurrence. Thus, an alternative therapeutic approach is needed. Recent evidence indicates a specific cell population of cancer stem cells or tumor initiating cells (jointly CSC) exists in various cancers that may be identified by cell surface markers, such as CD133, CD44, aldehyde dehydrogenase 1 (ALDH1) enzyme expression, or side population.

Why it matters

OpenAlex reports 6 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Are Cancer Stem Cells Responsible for Cancer Recurrence? Local recurrence or distant organ metastasis are the major causes of cancer mortality. Conventional treatments, including surgery, chemotherapy, and irradiation, do not consistently prevent cancer recurrence. Thus, an alternative therapeutic approach is needed. Recent evidence indicates a specific cell population of cancer stem cells or tumor initiating cells (jointly CSC) exists in various cancers that may be identified by cell surface markers, such as CD133, CD44, aldehyde dehydrogenase 1 (ALDH1) enzyme expression, or side population.

Key concepts: Cancer stem cell, CD44, Cancer, Cancer cell, Metastasis, Aldehyde dehydrogenase, Cancer research, Stem cell

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Are Cancer Stem Cells Responsible for Cancer Recurrence? — Research Paper | ScholarLens