2005•Protein and Peptide LettersRequires access

Hylins: Bombinins H Structurally Related Peptides from the Skin Secretion of the Brazilian Tree-Frog Hyla biobeba

Mariana S. Castro, Rubens Hisanari Matsushita, Antônio Sebben, Marcelo Valle de Sousa, Wagner Fontes

Abstract

Two hemolytic peptides were isolated from the skin secretion of the Brazilian Hylidae frog Hyla biobeba, using reversed-phase chromatographic procedures. Hylins b1 and b2 exhibit short linear polypeptide chains, a large number of hydrophobic residues, amidated C termini and hemolytic properties. These two novel peptides are the first examples of bombinins H-like peptides isolated from anurans species not related to Bombina species.

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Key concepts: Hyla, Tree frog, Frog Skin, Amphibian, Secretion, Hylidae, Biology, Salientia