1987•Brain ResearchOpen access

A vasoactive intestinal polypeptide system in retinal cell cultures: immunocytochemistry and physiology

Masakatsu Fukuda, Hermes H. Yeh, Donald G. Puro

Abstract

The purpose of this study was to search for vasoactive intestinal polypeptide (VIP)-like immunoreactivity and VIP-mediated effects in cultures containing cells from the mammalian retina. VIP-like immunoreactivity was detected by indirect immunocytochemistry within 6 days after plating dissociated retinal cells from embryonic day-19 rats. In electrophysiological experiments, VIP was found to facilitate evoked transmission at cholinergic synapses formed by retinal neurons in culture.

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Key concepts: Vasoactive intestinal peptide, Immunocytochemistry, Retinal, Retina, Biology, Neuropeptide, Endocrinology, Neuroscience