2009•International Archives of Allergy and Applied ImmunologyRequires access
Serum-Mediated Inhibition of Human Lymphocyte Fcγ-Receptors in Extrinsic and Intrinsic Bronchial Asthma
Fiona Reid, R. Stevenson, Neil C. Thomson, J. Elliot, G. P. Sandilands
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Abstract
Sera from 48 patients with extrinsic asthma and 37 with intrinsic asthma were screened for immune complexes using the EA-rosette inhibition assay. Significant levels of EA-rosette inhibition were found in both groups when compared with normal sera. The serum inhibitory factor(s) is, however, more likely to be an anti-lymphocyte antibody of the IgM class than an immune complex as originally expected.