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Neuroleptic-Induced "Anhedonia" in Rats: Pimozide Blocks Reward Quality of Food

Roy A. Wise, Joan Spindler, Harriet de Wit, Gary J. Gerberg

Open publisher page 642 citations

Abstract

The dopamine receptor blocker pimozide attenuated lever-pressing and running for food reward in hungry rats. In each case the characteristic behavior of pimozide-treated rats was the same as that of undrugged rats when reward was simply withheld. Drug-induced performance difficulties were ruled out by the presence of periods of normal responding in drug-treated animals. Pimozide appears to selectively blunt the rewarding impact of food and other hedonic stimuli.

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What this paper is about

The dopamine receptor blocker pimozide attenuated lever-pressing and running for food reward in hungry rats. In each case the characteristic behavior of pimozide-treated rats was the same as that of undrugged rats when reward was simply withheld. Drug-induced performance difficulties were ruled out by the presence of periods of normal responding in drug-treated animals. Pimozide appears to selectively blunt the rewarding impact of food and other hedonic stimuli.

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OpenAlex reports 642 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The dopamine receptor blocker pimozide attenuated lever-pressing and running for food reward in hungry rats. In each case the characteristic behavior of pimozide-treated rats was the same as that of undrugged rats when reward was simply withheld. Drug-induced performance difficulties were ruled out by the presence of periods of normal responding in drug-treated animals. Pimozide appears to selectively blunt the rewarding impact of food and other hedonic stimuli.

Key concepts: Pimozide, Anhedonia, Dopamine receptor, Dopamine, Psychology, Pharmacology, Neuroscience, Medicine

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Neuroleptic-Induced "Anhedonia" in Rats: Pimozide Blocks Reward Quality of Food — Research Paper | ScholarLens