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Glutamic Oxalacetic Transaminase Activity in the Ovary of Hypothyroid and Vitamin B6Deficient Rats

Benjamin Eckstein

Abstract

The effect of serum gonadotrophin (PMS) in stimulating glutamic-oxalacetic transaminase (GOT) activity in the ovary and uterus of rats was shown to be dependent on the reactivity of the ovary to gonadotrophin stimulation. In vitamin B6 deficient rats, in which the reactivity of the ovaries is lowered, even a dose as large as 40 IU of PMS does not change the low GOT activity of the ovary and uterus. On the other hand, in thiouracll-fed rats, in which the ovarian reactivity to gonadotrophin stimulation is enhanced, the stimulating effect of PMS on GOT activity is markedly increased. The deleterious effect of vitamin B6 deficiency on GOT activity is rapidly reversed after placing the rats for 5 days on normal diet.

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Key concepts: Internal medicine, Ovary, Endocrinology, Transaminase, Uterus, Stimulation, Chemistry, Biology