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1988•Drug Development and Industrial PharmacyRequires access

Lubricants as a Formulation Factor Affecting In Vitro Properties of Double Compressed Tablets

M. A. F. Gadalla, M. H. Abd El-Hameed, Ismail Aa

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Abstract

The effect of some lubricants and their concentrations on the in-vitro properties of aspirin tablets as a model of tablets prepared by double compression was studied. The formulated tablets were evaluated using the U.S.P XX official tests and some other selected non-official tests. These tests include: uniformity of weight, uniformity of content, disintegration, dissolution, hardness, friability and thickness. The obtained results showed that all the prepared formulae fulfilled the requirements of such tests. Talc at a concentration of 3% w/w was found to be the most suitable lubricant for the formulation of aspirin tablets. On the other hand, magnesium stearate was found to be the worst lubricant in this study.

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What this paper is about

The effect of some lubricants and their concentrations on the in-vitro properties of aspirin tablets as a model of tablets prepared by double compression was studied. The formulated tablets were evaluated using the U.S.P XX official tests and some other selected non-official tests. These tests include: uniformity of weight, uniformity of content, disintegration, dissolution, hardness, friability and thickness. The obtained results showed that all the prepared formulae fulfilled the requirements of such tests. Talc at a concentration of 3% w/w was found to be the most suitable lubricant for the formulation of aspirin tablets. On the other hand, magnesium stearate was found to be the worst lubricant in this study.

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OpenAlex reports 5 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

The effect of some lubricants and their concentrations on the in-vitro properties of aspirin tablets as a model of tablets prepared by double compression was studied. The formulated tablets were evaluated using the U.S.P XX official tests and some other selected non-official tests. These tests include: uniformity of weight, uniformity of content, disintegration, dissolution, hardness, friability and thickness. The obtained results showed that all the prepared formulae fulfilled the requirements of such tests. Talc at a concentration of 3% w/w was found to be the most suitable lubricant for the formulation of aspirin tablets. On the other hand, magnesium stearate was found to be the worst lubricant in this study.

Key concepts: Friability, Magnesium stearate, Lubricant, Talc, Materials science, Composite material, Dissolution, Stearate

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