2009•Nigerian Journal of Health and Biomedical SciencesRequires access

Anti-diabetic Potential of the Aqueous Leaf Extracts of Ocimum Gratissimum (Labiatae) and Vernonia Amygdalina Del. (Compositae) in Diabetic–Induced Rabbit

G.A. Ajayi, Mushafau Adewale Akinsanya, KO Ajibode, OA Magbagbeola

Abstract

The anti-diabetic potential of aqueous extracts of leaves of both Ocimum gratissimum and Vernonia amygdalina were investigated in rabbits. Ten female rabbits were grouped into five groups (1-5) of two rabbits each. Group 1 is the control. Groups (2-5) was alloxan induced diabetic. Group 3 was thentreated with 200mg/kg body wt. Ocimum gratissimum, group 4 was treated with 200mg/kg body wt. Vernonia amygdalina while group 5 was treated with 400mg/kg body wt. of b oth aqueous extracts in ratio 3: 1. The results showed a significant reduction in the plasma glucose in the treated rabbits.

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Key concepts: Vernonia amygdalina, Ocimum gratissimum, Alloxan, Traditional medicine, Ocimum, Diabetes mellitus, Medicine, Aqueous extract