Practical approaches to HIV therapy

Despite advances in treatment, HIV infection continues to present a daunting global medical challenge. Rapid development of new pharmaceutical agents has led to significant increases in the effectiveness of therapy. However, as use of antiretroviral drugs increases, so does our appreciation of the potential toxic effects of these agents. In-depth knowledge of HIV pathophysiology and the characteristics of individual drugs is mandatory for any physician caring for patients with HIV infection. In this article, Dr Wolfe outlines a practical approach to HIV therapy based on current consensus and his own recommendations.