METHODS OF ALTERING THE INCIDENCE OF EXPERIMENTAL ULCERS IN DRAGSTEDT ANIMALS

EXPERIMENTAL ulcers have been produced by many surgical and chemical methods. None has proved to be entirely satisfactory for the study of all phases of the ulcer problem in man. With the appearance of a large number of new antisecretory compounds, the need for an acute hypersecretion type of ulcer has developed. Dragstedt and others1showed that when the antrum of the stomach was transplanted to the large intestine a marked increase in gastric secretion occurred and that in animals so prepared ulcers tended to develop. The ulcers thus produced were acute (perforation occurred in about three weeks), and they involved the jejunum opposite the gastric stoma. Dragstedt demonstrated that in 80% of the animals on which a gastrojejunostomy was done with antral transplants to the colon jejunal ulcers developed in about 3 to 4 weeks and some as early as 10 days (Fig. 1). When we duplicated this