2014•Human & Experimental ToxicologyRequires access

Can anisodamine be a potential substitute for high-dose atropine in cases of organophosphate poisoning?

Wei Wang, Q-F Chen, H Ruan, K Chen, Bao‐Ji Chen, J-M Wen

Abstract

A case of organophosphate (OP) poisoning was admitted to the emergency room. The patient accepted treatment with pralidoxime (PAM), atropine, and supporting therapy. It was observed that even after 22 h after treatment, 960 mg of atropine was not enough for the patient to be atropinized. However, a 160-mg follow-up treatment of anisodamine was quite enough for atropinization after 4 h. As a case report, more studies are required before any definite conclusion can be reached regarding the use of anisodamine as a potential substitute for high-dose atropine in cases of OP poisoning.

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Key concepts: Anisodamine, Pralidoxime, Atropine, Organophosphate poisoning, Organophosphate, Medicine, Anesthesia, Pesticide