2001•Chinese Journal of Cancer ResearchRequires access
Expression of fas ligand in human colon cancer cell lines
Jianjun Zhang, Ding Er-xun, Qiang Wang, Xueyun Chen, Zhiren Fu
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Abstract
Objective: To investigate the expression of Fas ligand in human colon carcinoma cell lines. Methods: A total of six human colon cancer cell lines were examined for the expression of Fas ligand mRNA and cell surface protein by using RT-PCR and flow cytometry respectively. Results: The results showed that Fas ligand mRNA was expressed in all of the six cancer cell lines and Fas ligand cell surface protein was expressed in part of them. Conclusion: These data suggest that Fas ligand was expressed, at least in part, in human colon cancer cell lines and might facilitate to escape from immune surveillance of the host.