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1976•The Journal of Clinical Endocrinology & MetabolismRequires access

Suppression by Thyrotropin-Releasing Hormone (TRH) of Growth Hormone Release Induced by Arginine and Insulin-Induced Hypoglycemia in Man

Kiyoshi Maeda, YUZURU KATO, Kazuo Chihara, SHOZO OHGO, Yoshiko Iwasaki, Hiromi Abe, ANDHIROO IMURA

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Abstract

Plasma growth hormone (GH) levels were significantly increased following L-arginine (30 g) infusion or insulin (0.1 U/kg body wt)-induced hypoglycemia in normal men. When synthetic thyrotropin-releasing hormone (TRH) (1 mg) was infused intravenously for 150 min, beginning 30 min before arginine or insulin administration, GH responses to arginine and insulin were significantly blunted with a mean (+/- SE) percentage inhibition of 80.1 +/- 8.8% and 30.6 +/- 10.3%, respectively. These results suggest a possible inhibitory effect of TRH on GH secretion in man.

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What this paper is about

Plasma growth hormone (GH) levels were significantly increased following L-arginine (30 g) infusion or insulin (0.1 U/kg body wt)-induced hypoglycemia in normal men. When synthetic thyrotropin-releasing hormone (TRH) (1 mg) was infused intravenously for 150 min, beginning 30 min before arginine or insulin administration, GH responses to arginine and insulin were significantly blunted with a mean (+/- SE) percentage inhibition of 80.1 +/- 8.8% and 30.6 +/- 10.3%, respectively. These results suggest a possible inhibitory effect of TRH on GH secretion in man.

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Available abstract

Plasma growth hormone (GH) levels were significantly increased following L-arginine (30 g) infusion or insulin (0.1 U/kg body wt)-induced hypoglycemia in normal men. When synthetic thyrotropin-releasing hormone (TRH) (1 mg) was infused intravenously for 150 min, beginning 30 min before arginine or insulin administration, GH responses to arginine and insulin were significantly blunted with a mean (+/- SE) percentage inhibition of 80.1 +/- 8.8% and 30.6 +/- 10.3%, respectively. These results suggest a possible inhibitory effect of TRH on GH secretion in man.

Key concepts: Endocrinology, Internal medicine, Arginine, Insulin, Hypoglycemia, Thyrotropin-releasing hormone, Hormone, Growth hormone

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Suppression by Thyrotropin-Releasing Hormone (TRH) of Growth Hormone Release Induced by Arginine and Insulin-Induced Hypoglycemia in Man — Research Paper | ScholarLens