2002•The Journal of Organic ChemistryRequires access

Hydroformylation of Alkenes Employing Rhodium(I) Complexes and a Phosphine Oxide Ligand

Helen J. Clark, Ruiping Wang, Howard Alper

Abstract

Following the facile synthesis of a novel phosphine oxide compound, (diphenylphosphinoyl)phenylmethanol (1), this compound was employed as a ligand in the rhodium-catalyzed hydroformylation of alkenes, with good conversions and regioselectivities. This ligand was partially resolved using an enzyme, and enantioselective hydroformylation was carried out with the addition of a rhodium(I) complex. The rhodium(I) complex containing ligand 1 was not isolated, although it was subjected to low-temperature NMR studies.

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Key concepts: Hydroformylation, Rhodium, Chemistry, Ligand (biochemistry), Phosphine, Phosphine oxide, Enantioselective synthesis, Organic chemistry