Endurance Exercise Reduces Oxidative Stress in Mice

[Purpose] The purpose of this study was to investigate the effects of endurance exercise on glutathione in mice. [Subjects] Twelve mice were randomly assigned to one of two groups: the endurance exercise group (n=6), and the control group (n=6). [Methods] The exercise group ran on a motor driven treadmill 5 days per week for 30 minutes at a speed of 24 m·min-1 for 4 weeks. The ratio of GSH to GSSG was measured as an indicator of cardiac oxidative stress. The independent t test was used for statistical analysis. [Results] The results show that the endurance exercise significantly increased the ratio of GSH to GSSG in the exercised mice compared to the sedentary mice. [Conclusion] The results indicate that the four weeks of the endurance exercise reduced oxidative stress levels in mice.