1995•Chinese Journal of ChemistryRequires access

Direct synthesis of per(poly)fluoroalkylmethyl‐substituted electrophilic cyclopropane derivatives

Jian Chen, Chang‐Ming Hu

Abstract

Abstract A convenient and direct per(poly)fluoroalkylmethyl‐introducing cyclopropanation reaction was described. In the presence of CrCl3/Fe, per(poly)fluoroalkyl iodides reacted with diethyl allylmalonate and its analogs to give per(poly)fluoroalkymethyl‐substituted electrophilic cyclopropane derivatives in high yields. This reaction was considered to proceed by two steps: radical addition followed by cyclopropanation.

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Key concepts: Cyclopropanation, Cyclopropane, Chemistry, Electrophile, Organic chemistry, Medicinal chemistry, Catalysis, Ring (chemistry)