2013•Antimicrobial Agents and ChemotherapyOpen access

Detection of Linezolid-Resistant Staphylococcus aureus with 23S rRNA and Novel L4 Riboprotein Mutations in a Cystic Fibrosis Patient in Spain

Federico Román, Carolina Roldán, Pilar Trincado, Carmen Ballesteros, C Carazo, Ana Vindel

Abstract

Linezolid-resistant Staphylococcus aureus (LRSA) emerged in cystic fibrosis (CF) patients in different countries several years ago ([1][1]), and we have also observed this problem in Spain. The most frequent mechanism of linezolid resistance in staphylococci is a G2576T point mutation within domain

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Key concepts: Linezolid, 23S ribosomal RNA, Staphylococcus aureus, Cystic fibrosis, Microbiology, Medicine, Micrococcaceae, Biology