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2006•Analytical LettersRequires access

Precision in Capillary Electrophoresis

Imran Ali, Hassan Youssef Aboul-Enein, Vinod Kumar Gupta

Open publisher page 38 citations

Abstract

Method validation is one of the most important requirements of capillary electrophoretic (CE) methodologies. In spite of the advanced CE equipment available, this technique is still suffering with the problem of reproducibility due to certain nonconstant operational parameters. This article discusses the factors and reasons for nonreproducibility in CE methodologies, which include buffers, capillary, modes of injections, and applied voltage. Suggestions have also been presented to achieve maximum reproducibility in capillary electrophoresis experiments.

About this research paper

What this paper is about

Method validation is one of the most important requirements of capillary electrophoretic (CE) methodologies. In spite of the advanced CE equipment available, this technique is still suffering with the problem of reproducibility due to certain nonconstant operational parameters. This article discusses the factors and reasons for nonreproducibility in CE methodologies, which include buffers, capillary, modes of injections, and applied voltage. Suggestions have also been presented to achieve maximum reproducibility in capillary electrophoresis experiments.

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OpenAlex reports 38 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Method validation is one of the most important requirements of capillary electrophoretic (CE) methodologies. In spite of the advanced CE equipment available, this technique is still suffering with the problem of reproducibility due to certain nonconstant operational parameters. This article discusses the factors and reasons for nonreproducibility in CE methodologies, which include buffers, capillary, modes of injections, and applied voltage. Suggestions have also been presented to achieve maximum reproducibility in capillary electrophoresis experiments.

Key concepts: Capillary electrophoresis, Reproducibility, Chemistry, Capillary action, Chromatography, Electrophoresis, Materials science, Composite material

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