Lentiviral vector for hemophilia gene therapy

be relevant in patients with SLE.These include the known proapoptotic (antiendothelial cell antibodies, anti-dsDNA antibodies, lupus anticoagulant, inflammatory mediators, neutrophil proteases) and antiapoptotic (glucocorticoids, cyclosporine A) agents. 1,5 One approach could involve exposure of endothelial cells in vitro to serum from patients with SLE, neutralization of known proapoptotic factors to gain an impression of their relative importance in SLE, and testing of available antiapoptotic stimuli as agents that may be useful for subsequent clinical trials.This may permit a rational advance toward therapies that will improve the prognosis in patients with SLE.