1994•Antimicrobial Agents and ChemotherapyOpen access

Regulation of herpes simplex virus thymidine kinase in cells treated with a synergistic antiviral combination of alpha interferon and acyclovir

Jerry Taylor, Peggy Tom, James S. Guy, R M Selvarajan, William J. O’Brien

Abstract

Alpha interferon (IFN-alpha) and acyclovir (ACV) are synergistic in their anti-herpes simplex virus activities. IFN-alpha treatment reduced the herpes simplex virus thymidine kinase (TK) activity present in cells 6 h postinfection, while steady-state levels of TK mRNA remained at or above the amount in infected, untreated cells. The inhibition of TK production by IFN-alpha treatment appeared to be transient and translational, not transcriptional.

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Key concepts: Thymidine kinase, Herpes simplex virus, Alpha interferon, Virology, Interferon, Thymidine, Alpha (finance), Virus