1987•Chemical and Pharmaceutical BulletinOpen access
Amino acids and peptides. XIV Synthesis and biological activity of three S-peptide analogues of bovine pancreatic ribonuclease A (RNase A).
Naoki Teno, Satoshi Tsuboi, Tomoko Shimamura, Yoshio Okada, YOSHIMI YANAGIDA, Makiko YOSHINAGA, Kazuko Ohgi, Masachika IRIE
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Abstract
Three S-peptide analogues of bovine pancreatic ribonuclease A (RNase A), [Nle1] [Lys7] S-peptide (I), [Lys1] [Nle7] S-peptide (II) and [Nle1] [Nle7] S-peptide (III), were synthesized by the fragment condensation method and their ability to reactivate S-protein was examined. It was found that Lys1 and Lys7 both have roles in the reactivation of S-protein.
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