ScholarLens Back to search
1960•Archives of SurgeryRequires access

The Antrum

Niles D. Chapman

Open publisher page 2 citations

Abstract

Because the antrum is the source of the acid secretion stimulating hormone gastrin, it has been believed that a successful operation for duodenal ulcer includes removal of the antrum. Contrary to this view, we now know that the antrum can be retained,providedcertain criteria are followed. If the antrum is retained, it must ( 1 ) be vagally denervated; (2) remain in the acid stream; (3) have antral stasis prevented. The experimental basis for these criteria will be presented together with a brief review of the effect of various surgical procedures upon the antrum (Fig. 1). Experimental Normal Mechanisms of Gastric Acid Secretion A.Antral Stimulatory Mechanisms for Gastrin Release Edkins in 1906 demonstrated that the antral mucosa contained a hormone (gastrin) which, when injected intravenously, produced a copious secretion of HCl from a denervated stomach. Gastrin is released from the antrum in response to specific stimuli, which are: (1) Vagal:

About this research paper

What this paper is about

Because the antrum is the source of the acid secretion stimulating hormone gastrin, it has been believed that a successful operation for duodenal ulcer includes removal of the antrum. Contrary to this view, we now know that the antrum can be retained,providedcertain criteria are followed. If the antrum is retained, it must ( 1 ) be vagally denervated; (2) remain in the acid stream; (3) have antral stasis prevented. The experimental basis for these criteria will be presented together with a brief review of the effect of various surgical procedures upon the antrum (Fig. 1). Experimental Normal Mechanisms of Gastric Acid Secretion A.Antral Stimulatory Mechanisms for Gastrin Release Edkins in 1906 demonstrated that the antral mucosa contained a hormone (gastrin) which, when injected intravenously, produced a copious secretion of HCl from a denervated stomach. Gastrin is released from the antrum in response to specific stimuli, which are: (1) Vagal:

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Because the antrum is the source of the acid secretion stimulating hormone gastrin, it has been believed that a successful operation for duodenal ulcer includes removal of the antrum. Contrary to this view, we now know that the antrum can be retained,providedcertain criteria are followed. If the antrum is retained, it must ( 1 ) be vagally denervated; (2) remain in the acid stream; (3) have antral stasis prevented. The experimental basis for these criteria will be presented together with a brief review of the effect of various surgical procedures upon the antrum (Fig. 1). Experimental Normal Mechanisms of Gastric Acid Secretion A.Antral Stimulatory Mechanisms for Gastrin Release Edkins in 1906 demonstrated that the antral mucosa contained a hormone (gastrin) which, when injected intravenously, produced a copious secretion of HCl from a denervated stomach. Gastrin is released from the antrum in response to specific stimuli, which are: (1) Vagal:

Key concepts: Antrum, Gastrin, Medicine, Gastric antrum, Pyloric Antrum, Internal medicine, Gastric acid, Secretion

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
The Antrum — Research Paper | ScholarLens