1986•FEBS LettersOpen access
Turnover of rat liver ornithine transcarbamylase
Ruth Wallace, Erwin Knecht, Santiago Grisolı́a
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Abstract
The relative half-life of ornithine transcarbamylase from rat liver has been determined using the double isotope technique and affinity chromatography. The calculated half-life (6-9 days) is similar to that of mitochondria and of the other mitochondrial enzyme of the urea cycle, carbamoyl-phosphate synthase. Therefore, both mitochondrial urea cycle enzymes are most probably degraded mainly via the lysosomal (autophagic) pathway of mitochondrial protein degradation.
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