2015Lung CancerRequires access

I1171 missense mutation (particularly I1171N) is a common resistance mutation in ALK-positive NSCLC patients who have progressive disease while on alectinib and is sensitive to ceritinib

Sai‐Hong Ignatius Ou, Joel Greenbowe, Ziad U. Khan, Michele C. Azada, Jeffrey S. Ross, Phil J. Stevens, Siraj M. Ali, Vincent A. Miller, Barbara J. Gitlitz

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Key concepts: Alectinib, Crizotinib, Ceritinib, Anaplastic lymphoma kinase, ALK inhibitor, Medicine, Resistance mutation, Cancer research

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I1171 missense mutation (particularly I1171N) is a common resistance mutation in ALK-positive NSCLC patients who have progressive disease while on alectinib and is sensitive to ceritinib — Research Paper | ScholarLens