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2001•Applied SpectroscopyRequires access

Comparative Evaluation of Vibrational Circular Dichroism and Optical Rotation for Determination of Enantiomeric Purity

Chun‐Xia Zhao, Prasad L. Polavarapu

Open publisher page 11 citations

Abstract

Vibrational circular dichroism (VCD) is used to determine enantiomeric purity (EP) of three sample groups, and the results are compared with those obtained from optical rotation. In most typical cases EP determination from optical rotation is more accurate than that from VCD. However, in cases where either optical rotation is very small or different chiral samples are present as a mixture, EP determination from VCD provides definite advantages with reasonable accuracy.

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What this paper is about

Vibrational circular dichroism (VCD) is used to determine enantiomeric purity (EP) of three sample groups, and the results are compared with those obtained from optical rotation. In most typical cases EP determination from optical rotation is more accurate than that from VCD. However, in cases where either optical rotation is very small or different chiral samples are present as a mixture, EP determination from VCD provides definite advantages with reasonable accuracy.

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OpenAlex reports 11 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Vibrational circular dichroism (VCD) is used to determine enantiomeric purity (EP) of three sample groups, and the results are compared with those obtained from optical rotation. In most typical cases EP determination from optical rotation is more accurate than that from VCD. However, in cases where either optical rotation is very small or different chiral samples are present as a mixture, EP determination from VCD provides definite advantages with reasonable accuracy.

Key concepts: Optical rotation, Vibrational circular dichroism, Circular dichroism, Enantiomeric excess, Enantiomer, Chemistry, Rotation (mathematics), Specific rotation

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