An Efficient Synthesis and Selective Reaction of N-Substituted Isothiazolidinium Salts

The fust example of the preparation of N-acylated isothiazolidinium salts is described, and the sta.bility and reactivity of the isothiazolidinium salts are found to be highly dependent upon the substituent at the nitrogen atom.Dehydromethionine (I)]-3 having an isothiazolidinium structure was prepared by oxidative cyclization of an amino acid, methionine, and has been received considerable attention because of its important physiological