2006•CellOpen access

Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

Raúl Mostoslavsky, Katrin F. Chua, David B. Lombard, Wendy W. Pang, Miriam R. Fischer, Lionel Gellon, Pingfang Liu, Gustavo Mostoslavsky, Sonia Franco, Michael Murphy, Kevin D. Mills, Parin Patel, Joyce T. Hsu, Andrew L. Hong, Ethan Ford, Hwei-Ling Cheng, Caitlin Kennedy, Nomelí P. Núñez, Roderick T. Bronson, David Frendewey, Wojtek Auerbach, David M. Valenzuela, Margaret Karow, Michael O. Hottiger, Stephen D. Hursting, J. Carl Barrett, Leonard Guarente, Richard Mulligan, Bruce Demple, George D. Yancopoulos, Frederick W. Alt

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Key concepts: Biology, Genome instability, Phenotype, Genetics, Instability, SIRT6, Evolutionary biology, Gene