1955•Experimental Biology and MedicineRequires access

Effect of Isonicotinic Acid Hydrazide on Niacin and Pyridoxine Metabolism in Rats

Fred S. Rosen

Abstract

INH did not inhibit any of the normal pathways of niacin metabolism investigated in the rat. When added to a B6-deficient ration INH had a pronounced toxic effect characterized by inhibition of growth, decreased survival time and epileptiform convulsions. The elevated excretion of xanthurenic acid; considered characteristic of the B6-deficient rat, was not apparent in INH-treated animals.

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Key concepts: Xanthurenic acid, Niacin, Pyridoxine, Isonicotinic acid, Pyridoxine Deficiency, Metabolism, Hydrazide, Excretion