Lysis of Neonatal Human Erythrocytes in Hypotonic Solutions of Glucose

The rate of lysis of neonatal and adult human red cells in hypotonic solutions of glucose 0.116 and 0.118 m is examined, using an automatic procedure (Fragiligraph). The lysis of neonatal red cells is similar to the lysis of adult red cells. The decrease in osmotic concentration of D-glucose solution induces an increase in the rate of lysis more significantly in neonatal red cells. High density old red cells are the first to lyse in hypotonic solutions of glucose.