VISCOSIMETRIC STUDY OF THE ACTION OF ε-AMINO-CAPROIC ACID ON HUMAN PLASMIN

By means of the viscosimetric method, the inhibitory effect of E-A.C.A. on plasmin caseinolysis was studied.(1) ε-A. C. A. inhibits competitively S. K.-activation process of human plasminogen.(2) a) At high concentrations, over 2%, ε-A. C. A. inhibits noncompetitively caseinolytic activity of plasmin produced from human globulin with S. K.b) At low concentrations, below 1%, it enhances caseinolytic activity of plasmin.This enhancing effect was not seen when ε-A.C.A. was added to casein before the latter was affected by plasmin. (Fig. 6)I should like to thank the members of the Technical Center of the ResearchProject on Plasmin and Antiplasmin and Prof. S. Okamoto.