1978•Nutrition and CancerRequires access

Inhibition of in vitro metabolic activation of carcinogens by wheat sprout extracts

Chiu‐Nan Lai, Betty J. Dabney, Charles R. Shaw

Open publisher page 44 citations

Abstract

Extracts from the roots and the leaves of wheat sprouts selectively inhibited the mutagenic effect of carcinogens requiring metabolic activation as demonstrated in the Ames Salmonella/ mammalian‐microsome test. Formation of dihydrodiol metabolites of benzo(a)pyrene was significantly reduced, as seen in high‐pressure liquid chromatographic profiles of metabolites.

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What this paper is about

Extracts from the roots and the leaves of wheat sprouts selectively inhibited the mutagenic effect of carcinogens requiring metabolic activation as demonstrated in the Ames Salmonella/ mammalian‐microsome test. Formation of dihydrodiol metabolites of benzo(a)pyrene was significantly reduced, as seen in high‐pressure liquid chromatographic profiles of metabolites.

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Available abstract

Extracts from the roots and the leaves of wheat sprouts selectively inhibited the mutagenic effect of carcinogens requiring metabolic activation as demonstrated in the Ames Salmonella/ mammalian‐microsome test. Formation of dihydrodiol metabolites of benzo(a)pyrene was significantly reduced, as seen in high‐pressure liquid chromatographic profiles of metabolites.

Key concepts: Carcinogen, In vitro, Microsome, Pyrene, Chemistry, Ames test, Salmonella, Benzo(a)pyrene

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