Inhibition of in vitro metabolic activation of carcinogens by wheat sprout extracts
Chiu‐Nan Lai, Betty J. Dabney, Charles R. Shaw
Abstract
Chiu‐Nan Lai, Betty J. Dabney, Charles R. Shaw
Abstract
Extracts from the roots and the leaves of wheat sprouts selectively inhibited the mutagenic effect of carcinogens requiring metabolic activation as demonstrated in the Ames Salmonella/ mammalian‐microsome test. Formation of dihydrodiol metabolites of benzo(a)pyrene was significantly reduced, as seen in high‐pressure liquid chromatographic profiles of metabolites.
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Extracts from the roots and the leaves of wheat sprouts selectively inhibited the mutagenic effect of carcinogens requiring metabolic activation as demonstrated in the Ames Salmonella/ mammalian‐microsome test. Formation of dihydrodiol metabolites of benzo(a)pyrene was significantly reduced, as seen in high‐pressure liquid chromatographic profiles of metabolites.
Key concepts: Carcinogen, In vitro, Microsome, Pyrene, Chemistry, Ames test, Salmonella, Benzo(a)pyrene