1979•NeurologyRequires access
Valproic acid and plasma levels of phenytoin
J. Bruni, B. J. Wilder, L. James Willmore, Benjamin H. Barbour
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Abstract
Eight patients were treated concurrently with a constant dose of phenytoin and valproic acid for 1 year. During initial therapy with valproic acid, total plasma phenytoin levels decreased. The interaction was transient and was not observed at the end of 1 year. Total plasma phenytoin levels returned to pre-valproic-acid levels in seven patients.