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2004•European Journal of Gastroenterology & HepatologyRequires access

Acid, weakly acidic and non-acid gastro-oesophageal reflux

Daniel A. Sifrim

Open publisher page 64 citations

Abstract

In patients with gastro-oesophageal reflux disease (GORD), oesophageal symptoms and mucosal damage traditionally are related to acid-reflux episodes with pH lower than 4. Oesophageal or extra-oesophageal symptoms of GORD may also be associated with less acidic reflux (pH 4-7). New methodologies have evolved to complement pH monitoring for characterisation of less acidic gastro-oesophageal reflux. This review will focus on definition, detection, pathophysiology and symptom association of weakly acidic and non-acid reflux, in both adult and paediatric populations.

About this research paper

What this paper is about

In patients with gastro-oesophageal reflux disease (GORD), oesophageal symptoms and mucosal damage traditionally are related to acid-reflux episodes with pH lower than 4. Oesophageal or extra-oesophageal symptoms of GORD may also be associated with less acidic reflux (pH 4-7). New methodologies have evolved to complement pH monitoring for characterisation of less acidic gastro-oesophageal reflux. This review will focus on definition, detection, pathophysiology and symptom association of weakly acidic and non-acid reflux, in both adult and paediatric populations.

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OpenAlex reports 64 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

In patients with gastro-oesophageal reflux disease (GORD), oesophageal symptoms and mucosal damage traditionally are related to acid-reflux episodes with pH lower than 4. Oesophageal or extra-oesophageal symptoms of GORD may also be associated with less acidic reflux (pH 4-7). New methodologies have evolved to complement pH monitoring for characterisation of less acidic gastro-oesophageal reflux. This review will focus on definition, detection, pathophysiology and symptom association of weakly acidic and non-acid reflux, in both adult and paediatric populations.

Key concepts: Reflux, Gastro-, Medicine, Gastroenterology, Internal medicine, Pathophysiology, Disease, Esophageal disease

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