1984•International Journal of Radiation Biology and Related Studies in Physics Chemistry and MedicineRequires access

Differential Recovery from Potentially Lethal Damage in Normal Human Lung Fibroblasts after Irradiation with 60 Co γ-rays and Accelerated N-ion Beam

Tadao Ohno, Tetsuji Nishimura, Kazushiro Nakano, Ichiro Kaneko

Abstract

PLD recovery after irradiation with accelerated N-ion was examined and compared with that after irradiation with 60Co gamma-rays in normal human lung fibroblasts (IMR-90). No shoulder region was observed in the survival curve of the cells after N-ion irradiation. Ratios of D0 values before and after a 6-hour incubation in plateau phase were 1.1 and 1.8 for N-ion irradiation and gamma-ray irradiation, respectively. The results show that recovery after irradiation with high-LET radiation is slow and much less than after low-LET irradiation.

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Key concepts: Irradiation, Radiochemistry, Ion, Radiobiology, Radiation damage, Chemistry, Materials science, Nuclear medicine