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Highly Enantioselective Synthesis of Heteroaromatic Alcohols Catalyzed by Chiral Diaminodiphosphine-Ruthenium(II) Complexes

Jing‐Xing Gao, Weiyi Shen, Yanyun Li, Zhen‐Rong Dong

Abstract

Chiral diaminodiphosphine-ruthenium(II) complexes were found to be excellent catalysts for the asymmetric transfer hydrogenation of heteroaromatic ketones in propan-2-ol. In the presence of potassium hydroxide, the enantioselective reduction of heteroaromatic ketones proceeded smoothly to give chiral alcohols with excellent enantiomeric excess (up to 97% ee) under mild conditions without reduction of the heterocycle.

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Available abstract

Key concepts: Chemistry, Enantioselective synthesis, Ruthenium, Catalysis, Transfer hydrogenation, Enantiomer, Potassium hydroxide, Noyori asymmetric hydrogenation