1987•International Journal of Radiation Biology and Related Studies in Physics Chemistry and MedicineRequires access

The Inhibitory Effect of Succinate on Radiation-enhanced Mitochondrial Lipid Peroxidation

É. RÓNAI, László Tretter, Gyorgy Szabados, István T. Horváth

Abstract

The degree of mitochondrial ADP/Fe/NADPH-induced lipid peroxidation was increased up to the fourth day after 9.0 Gy whole body gamma-irradiation. The lipid peroxidation inhibiting effect of succinate added to isolated mitochondria was diminished as a consequence of irradiation. The succinate, administered in vivo prior to irradiation, decreased the amount of malondialdehyde production and protected the succinate dehydrogenase enzyme against inactivation. The mean survival of succinate-pretreated animals was much longer than that of controls. The role of mitochondrial lipid peroxidation in the pathogenesis of radiation injury is discussed.

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Key concepts: Lipid peroxidation, Inhibitory postsynaptic potential, Mitochondrion, Chemistry, Biochemistry, Pharmacology, Biophysics, Biology