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Isolated Adrenal Cortex Cells: Hypersensitivity to Adrenocorticotropic Hormone after Hypophysectomy

George Sayers, Robert J. Beall

Abstract

Cells from the adrenals of hypophysectomized rats (up to 28 days after operation) require less adrenocorticotropic hormone to induce one-half maximal rate of production of 3',5'-adenosine monophosphate than do cells from the adrenals of intact rats. A corresponding increase in sensitivity is reflected in the steroidogenic response to adrenocorticotropic hormone up to 2 days after hypophysectomy.

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Key concepts: Adrenocorticotropic hormone, Hypophysectomy, Internal medicine, Endocrinology, Adrenal cortex, Hormone, Chemistry, Medicine