2013•Clinical TherapeuticsOpen access

PP176—Comparison of Inhibitory Duration of Grapefruit Juice on Organic Anion-Transporting Polypeptide and CYP3A4

S. Tanaka, Shinya Uchida, Sachiko Miyakawa, Naoki Inui, Kazuhiko Takeuchi, Hiroshi Watanabe, Noriyuki Namiki

Abstract

Grapefruit juice (GFJ) is known to decrease the plasma concentrations of several drugs by inhibiting organic anion-transporting polypeptide (OATP) 2B1. We aimed to determine the duration of the inhibitory effect of GFJ on OATP by comparison with the duration of the GFJ-mediated effects on cytochrome P450 (CYP) 3A4 activity.

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Key concepts: Grapefruit juice, CYP3A4, Organic anion-transporting polypeptide, Inhibitory postsynaptic potential, Medicine, Pharmacology, Cytochrome P450, Food science