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2006•Nature Structural & Molecular BiologyRequires access

Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1

Jon C. D. Houtman, Hiroshi Yamaguchi, Mira Barda‐Saad, Alex Braiman, Brent Bowden, Ettore Appella, Peter Schuck, Lawrence E. Samelson

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Key concepts: Signal transducing adaptor protein, GRB2, Effector, Cell biology, SH2 domain, SH3 domain, Phosphorylation, Signal transduction

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