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Antireproductive Effects of a Potent Gonadotropin-Releasing Hormone Antagonist in the Male Rat

CATHERINE L. RIVIER, Jean Rivier, Wylie Vale

Abstract

Administration of a potent antagonist of gondadotropin-releasing hormone (GnRH) antagonist [Ac-dehydro-Pro1, pCl-D-Phe2, D-Trp3,6]-N alpha-MeLeu7-GnRH to adult male rats for 2 weeks resulted in decreased testosterone production and sexual organ weights and in disrupted spermatogenesis. The results demonstrate the essential role of gonadotropin-releasing hormone in the maintenance of reproductive functions and have implications for the regulation of male fertility.

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Key concepts: Antagonist, Internal medicine, Endocrinology, Hormone antagonist, Testosterone (patch), Gonadotropin-releasing hormone, Gonadotropin-releasing hormone antagonist, Hormone