2004•Journal of Chinese Integrative MedicineRequires access

Effect of ultra-fine powder technique on dissolution rates of andrographolide and dehydroandrographolide in Andrographis paniculata

Rongli Qiu

Abstract

OBJECTIVE: To investigate the effects of ultra-fine powder technique on dissolution rates of the components in Andrographis paniculata. METHODS: High performance liquid chromatography was employed to determine the concentration of andrographolide and dehydroandrographolide in common powdered or ultra-fine powdered Andrographis paniculata. RESULTS: The dissolution rates of andrographolide and dehydroandrographolide in ultra-fine powdered Andrographis paniculata were higher than those of the general powder. CONCLUSION: Ultra-fine powder technique promotes the dissolution rates of andrographolide and dehydroandrographolide.

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Key concepts: Andrographolide, Andrographis paniculata, Dissolution, Chemistry, Traditional medicine, Chromatography, Biochemistry, Medicine