1976•Clinical EndocrinologyRequires access

INCREASED SOMATOSTATIN CONTENT OF ISLETS FROM STREPTOZOTOCIN‐DIABETIC RATS

Yogesh Patel, Gordon C. Weir

Abstract

Pancreatic islets were isolated from control and streptozotocin-diabetic rats. Somatostatin content as determined by radioimmunoassay was strikingly increased in the diabetic group. Immunoreactive insulin content was markedly reduced and glucagon was moderately increased. The mechanisms responsible for the somatostatin changes are unknown.

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Key concepts: Internal medicine, Endocrinology, Somatostatin, Streptozotocin, Glucagon, Islet, Radioimmunoassay, Pancreatic islets